1. Hydroxychloroquine is a recognized therapy for patients with pSS.

2. Chloroquine(CQ) and hydroxychloroquine(HCQ) designated as 4-amino quinoline are the antimalarial medications(AMS).

3. Antimalarial agent, such as chloroquine and hydroxychloroquine, are widely used in the treatment of autoimmune diseases in recent years, particular in rheumatoid arthritis.

4. Previous evidence from animal studies suggests that hydroxychloroquine has an antidiabetic effect.

5. Evidence for the safety of hydroxychloroquine was better vs chloroquine.

6. Dr. Wasko and her associates recommend consideration of hydroxychloroquine as a standard component of treatment for rheumatoid arthritis.

7. The effect of hydroxychloroquine ( HCQ ) in the treatment of discoid lupus ery thematosus ( DLE ) and its side effects were observed.

8. Methotrexate plus hydroxychloroquine is recommended for patients with moderate to high disease activity regardless of disease duration or poor prognostic features.

9. Putting together, we suggest that corticosteroids and hydroxychloroquine for treating SLE activity are able to control thyroid inflammation and hypothyroid function.

10. Roughly one-third (1808) had taken hydroxychloroquine for some period of time during the study, with duration of treatment averaging 3.1 years.

11. Objective To investigate the effect and safety of hydroxychloroquine(HCQ)on serum uric acid(UA)in gout arthritis.

12. Hydroxychloroquine plus sulfasalazine is recommended only for patients with intermediate disease duration (6 - 24 months) and high disease activity but without poor prognostic features.

13. Further work is needed to explore this possibility and we intend to determine the in vivo effect of hydroxychloroquine on salivary cholinesterase following 6 months of therapy.

14. Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial.

15. In addition, we have speculated on a new mechanism for the action of hydroxychloroquine leading to an improvement in salivary flow rate.

16. Also during this time, researchers recorded incident diabetes in 54 patients who had taken hydroxychloroquine at some point vs 171 patients who had never taken the drug.

17. Overall, the hazard ratio for incident diabetes among patients who had taken hydroxychloroquine was 0.62% compared with those who had never taken it (95% confidence interval,() 0.42 – 0.92).

18. In addition, the transition of hyperthyroidism to hypothyroidism occurred in the medication of SLE with steroids and hydroxychloroquine.

19. Objective:To establish a method of RP IP HPLC determination for hydroxychloroquine sulfate tablets.

20. The reviewers found high-quality evidence that antimalarial therapy, especially hydroxychloroquine, given to pregnant women with SLE, can reduce lupus activity without harmful effects on the fetus.

21. Of the 4905 patients included in this analysis, 1808 (37%) reported hydroxychloroquine use at some time during the observation period.

22. In multivariable analysis, the hazard ratio for incident diabetes was 0.62 for the hydroxychloroquine group compared to the others.