1. There have been no extensive studies of xenobiotic metabolising enzyme expression in colonic adenomas.

2. A high dose dexamethasone test is used to differentiate adrenal hyperplasia from adrenal adenoma or carcinoma.

3. Lipkin proposed that upward expansion of the proliferative compartment of the crypts of the large intestine occurs before adenoma development.

4. By contrast all the enzyme forms studied were expressed in virtually all adenomas and in over half the carcinomas.

5. In addition, mast cells in normal colon, adenoma,(/adenomata.html) or carcinoma samples consistently showed strong positive staining for cytochrome P450 3A.

6. Our data are also consistent with observations in man that mucosal proliferation is increased in patients with large adenomas or cancer.

7. Nor do we yet have evidence that removal of proximal adenomas prevents proximal colon cancer.

8. A range of genetic alterations have recently been described in colorectal cancer and its benign precursor, the large bowel adenoma.

9. The value obtained in these benign tubulovillous adenomas was significantly raised relative to both normal and malignant tissues.

10. Total colectomy was performed because of incomplete removal of a large tubular adenoma with intra-epithelial malignant change.

11. Each digestion included a positive colorectal carcinoma or adenoma control known to contain a mutation at codon 12.

12. Histology of resected polyps revealed adenomata. Coexistent malignancy was found in 12.3% of polyps.