1. Key words pepper, piperine, irradiation, liquid chromatography.

2. Conclusions Piperine may prevent the formation of cholesterol gallstone through inhibiting the lithogenic role of APN.

3. Objective To investigate antidepressant-like effects and mechanisms of piperine and its derivative, 3,4-methylene dioxy cinnamoyl piperidine(MDP).

4. OBJECTIVE: To a method for the determination of piperine in Shiwei Doukou pill.

5. Objective : To determine the content of piperine long pepper - 3 powder.

6. RESULTS Piperine could reduce the spontaneous activity of mice and prolong the sleep time induced by sodium pentobarbital. It could also prolong the deep sleep of rabbits.

7. OBJECTIVE To determine the content of piperine in weibishu capsule by RP - HPLC.

8. Object; To explore the influence on liver cytochromes P450 by co-administration of piperine and glycyrrhizic acid in rat.