1. Saquinavir was the first protease inhibitor to be approved, but was soon surpassed by more effective drugs in the same class.

2. Synthesis of saquinavir, an HIV protease inhibitor, was researched via convergence method.

3. Saquinavir is taken in combination with other medicines. It is used to treat H. I. V. patients with or without AIDS.

4. OBJECTIVE To develop a HPLC assay for the determination of saquinavir and its related substances.

5. Aim To investigate the effect of ketoconazole on the metabolism in vitro and pharmacokinetics of saquinavir.