1 Cell transformation Cancer cells become tumorigenic as a result of multiple independent steps which subvert the normal growth control mechanisms described earlier.

2 Results The tumorigenic rate was 100%.

3 Anomalous proteins engaged in support of this tumorigenic regulatory environment most probably represent optimal intervention targets in a heterogeneous population of cancer cells.

4 Conclusion Non- tumorigenic transformed cell can be served as a standard cell line to study the function and growth characteristics of normal cell.

5 This genetic signature of tumorigenic breast-cancer cells was even more strongly associated with clinical outcomes when combined with the WR signature in breast cancer.

6 The isolation and characterization of tumorigenic colon cancer cells may help to devise novel diagnostic and therapeutic procedures.

7 Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour - initiating cells.

8 Furthermore,[] we found that HPV-positive dysplastic and tumorigenic cervical lesions were characterized by high levels of EZH2 protein in vivo.

9 This genetic signature of tumorigenic breast-cancer cells was een more strongly associated with clinical outcomes when combined with the WR signature in breast cancer.

10 It is assumed that this tumorigenic feature will be manifested upon transplantation to human patients as well.

11 In addition(), there are also indications that this signalling pathway can induce cells to become tumorigenic.

12 Invitro, oncogenes cooperate to transform cells and render them tumorigenic.

13 This Perspective emphasizes the differences between the transcriptional network that operates under normal homeostatic conditions and the network in a tumorigenic milieu.

14 Citrinin is a mycotoxin which can induce renal dysfunction, and it is tumorigenic.

15 Cell cycle analysis by flow cytometer showed higher S phase fractions in the high tumorigenic cells.

16 Results Normal biological characteristics and cell function could be maintained in non- tumorigenic transformed cell, but it was changed markedly in malignant transformed cell.

17 In addition, TSCs are located in the special microenvironment, and the interactions between TSCs and their microenvironment have a profound influence on the tumorigenic pro-cess.

18 We developed an immunodeficient mouse model to test the tumorigenic potential of different populations of cancer cells derived from primary, unmanipulated human HNSCC samples.

19 Could it indicate that each of them has unique tumorigenic mechanisms?

20 Since then, the investigation of cancer stem cell biology has exploded, as labs across the world continue to find similar subpopulations of tumorigenic cells in other forms of cancer.

21 Method: Observing the effects of alcohol extract from Sesamum indicum flower on tumor growth in sarcoma 180 ( S180 ) and Heps 22 ( H22) tumorigenic mouse, and on weight of immune organs.

22 They also found these cells are at least 100 times more tumorigenic than cancer cells that did not have one of three protein markers they believe to be associated with pancreatic cancer stem cells.

23 S100A4 knockdown in HN-CICs reduced their self-renewal capability and their stemness and tumorigenic properties, both in vitro and in vivo.