1 The superoxide generated may have a direct cytotoxic effect or it may interact with inflammatory mediators to modify the inflammatory process.

2 Supervised clinical training is provided in cytotoxic drug treatment and radiation therapy.

3 Cytotoxic drugs are classed by how they affect cells.

4 MTr test showed that curcumin was cytotoxic to cells.

5 As nickel released from nickel - titanium alloy cytotoxic,[] increasing nickel - titanium alloy ? ? s corrosion resistance is becoming important.

6 The cells when exposed to cytotoxic agents, the apoptosis lead to cell death.

7 The cytotoxic effects of NDV ( Losota 4 ) were investigated on multicellular spheroid of human lung adenocarcinoma A 549.

8 Its cytotoxic activity can be neutralized by monoclone antibody against hLT.

9 Killer or cytotoxic T cells destroy infected and foreign cells.

10 In vitro cytotoxicity test, the two prodrugs were slightly less cytotoxic than the intermediate, while greatly less cytotoxic than the parent compound camptothecin.

11 Objective To investigate the cytotoxic effect of fraction C from Naja Naja atra venom (FC) on human glioma cell line (U251).

12 May be involved in cytotoxic T cell mediated apoptosis and in T cell development.

13 Aim To investigate the cytotoxic activity of HDAC inhibitor Trichostatin A (TSA)combined with anticancer drugs targeting DNA on T24 bladder cancer cell line.

14 The cytotoxic and cytogenetic effect of sodium arsenite and sodium arsenate on Chinese hamster ovary (CHO) cells is reported.

15 Conclusion: STT exerts its cytotoxic effect on BEL - 7402 cells by inducing apoptosis.

16 Objective To study the injurious mechanism and the cytotoxic effect of lysophosphatidic acid(LPA) on primary rat cerebellar granule cells.

17 For example, acetaldehyde has been shown to form circulating cytotoxic adducts with serum albumin.

18 Patients were excluded if they had taken ulcer healing agents, antibiotics, or cytotoxic drugs within one week of endoscopy.

19 The mechanism by which chronic-phase CML cells become resistant to conventional cytotoxic drugs, such as hydroxyurea, is unknown.

20 The authors give an account of the basic concept and classification of cytotoxic drugs.

21 Lichen metabolites exert a wide variety of biological actions including antibiotic, antimycobacterial, antiviral, antiinflammatory, analgesic, antipyretic, antiproliferative and cytotoxic effects.

22 Objective To establish a simple animal model and the cytotoxic T cell(CTL) detecting system for the studies of the effects of CTL on HCV infection.

23 Conclusion A ? ? 25 - 35 may exert cytotoxic effects on VSMC through apoptotic pathway.

24 Objective To study the relationship between recurrent spontaneous abortion and the cytotoxic effect of NK cells.

25 The binding of antigenic peptide sequences to major histocompatibility complex(MHC) molecules is a prerequisite for stimulation of cytotoxic T cell responses.

26 Results: The bispecific antibody could induce P BLs to cytotoxic test of colonic cells in vivo.

27 Limonoids from the Melia family which have been reported to show significant cytotoxic activity were also reviewed.

28 Growing awareness of the similarities between "primary" amyloidosis and that associated with myelomatosis led to the trial of cytotoxic drug such as melphalan in the former condition(19)(20).

29 A common response of clinical researchers has been to reduce the dose of the cytotoxic agents.

30 Infection with cytomegalovirus is widespread and commonly believed to be both asymptomatic in immunocompetent individuals and unbeatable without the use of highly cytotoxic drugs.

31 The potency of capsaicin as an immuno- active ligand together with its cytotoxic effects and the induction of a specific immune response could make it an attractive candidate for cancer immunotherapy.

32 Thus, a hypercalcemia -induced cytotoxic effect in the central nervous system may play an important role in neuropsychiatric manifestations.

33 Anthraquinones are also reported to have antiprotozoal and cytotoxic activities.

34 Cytotoxic edema and blood brain barrier breakdown may be seen as decreased diffusion and enhancement, respectively, in thalami ,[] and these manifestations may less commonly extend to basal ganglia.

35 The cytotoxic effect of paclitaxel liposome on human lung adenocarcinoma cell line SPC-A1 in vitro was detected by thiazolyl blue(MTT) assay.

36 Methods: The effect of Rhodiola sachalinensis extracts at various concentrations on T241 fibrosarcoma cells proliferation and cytotoxic potential were measured.

37 So routine cytotoxic anti - tumor medicine are not competitive with mono antibody anti - tumor medicine in clinical application.

38 Mordern pharmacology research suggests Pachysandra terminalis has the activities of cytotoxic, anti-ulcer and exhibiting anticholinesterase activity.

39 Displays cytostatic and cytotoxic activity. Inhibitor of EGFR kinase. Shows antiangiogenic activity.

40 It is widely accepted that cytotoxic T cell(CTL) response to HBV infection was the primary effector cells by killing infected cells and clearing the virus, however(), CTL can also induce hepatic damage.

41 Objective To explore the associations between glucokinase(GCK) gene, cytotoxic T cell antigen-4(CTLA-4) gene and gestational diabetes mellitus(GDM).

42 The activation of inflammatory cells and cytotoxic effect also participate the pathogenesis.

43 Interleukin-2 causes the proliferation of certain cytotoxic T cell and B cells.

44 These T cells are sometimes referred to as cytotoxic T cells.

45 Antigen density on the tumor cell surface influences the cytotoxic sensitivity.

46 We measured lymphocyte subsets by flow cytometry, IL-2 and IL-4 lever by ELISA, and cytotoxic activity of NK, cytokines, CTL against K562, HL-60 and isogenous lymphocytes by cell culture.

47 These compounds activate dendritic cells to produce proinflammatory cytokines, which in turn trigger cytotoxic mechanisms leading to cancer death.

48 Objective Lactate-based peritoneal dialysis solutions (L-PDS) showed cytotoxic effect to human peritoneal mesothelial cells (HPMC).

49 AIM: To compare the cytotoxic effect of evodiamine with chemotherapy drugs on A375-S2 cells, and to examine the relationship between the effects of PKC and ERK on evodiamine-induced cell death.

50 It is postulated that the vaccines elicit effective but selective cell-mediated cytotoxic immune responses against HIV, HBV and HCV-infected cells.

51 Others produce cytotoxic injury, and some characteristically produce the mixed pattern.

52 This is seen in immunosuppressed patients usually on steroids, azathioprine, or cytotoxic agents following transplantation or for leukaemia or lymphoma.

53 Pathological change is chronic and continual advancement, patients can emerge renal inadequacy, uraemia. excitatory autacoid and cytotoxic drug have bad curative effect and major adverse reaction.

54 Navebine is a new semi-synthetic cytotoxic drug. Distinctive anticancer activity was observed in the treatment of 32 patients with non-small cell lung cancer.

55 OBJECTIVE : To study the cytotoxic effect in vitro and antitumor effect in vivo of hypericum chinense.

56 Myriocin induces apoptosis by depletion of cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant.