1. Nucleosome is the basic unit of chromatin.

2. The general features of nucleosome structure appear to be similar in all eukaryotes.

3. Alterations in nucleosome structure affect the accessibility of the DNA and can generate specialized domains of chromatin in the genome.

4. The protein-DNA nucleosome complexes, in turn, are packed into repeating units called chromatin, which is the building block of chromosomes.

5. Histones , as basic components of nucleosome, are essential to chromatin structure and function.

6. The nucleosome is therefore a key target of genetic processes in a cell and a focus of scientific investigations into how normal and diseased cells work.

7. Histones, as the basic components of nucleosome, are essential to chromatin structure and function.

8. The highly conserved globular domain is essential for the binding of H1 to the nucleosome.

9. Histone H3 is one of the four histones, along with H2A, H2B, and H4, which form the eukaryotic nucleosome octamer core.

10. These modifications regulate histone-DNA interactions, adding a new dimension to the epigenetic regulation of nucleosome mobility.

11. To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants tails.

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12. Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs.

13. Chromatin --- The complex of DNA and proteins of which chromosomes are composed. See also nucleosome.

14. An octa-mer of histones package DNA into a structure called a nucleosome.

15. DNA wraps around histones in left-handed way and forms nucleosome structure. Many nucleosomes are linked together like "prayer beads".

16. It has been known for some time that the acetylation of N-termini of core histones in nucleosome is associated with gene activation.

17. In eukaryotic cells, the fundamental unit of chromatin is nucleosome, which is composed of a histone octamer with two copies of HA, HB, H and H and base pairs of DNA.