1. Objective:To verify the possibility of odontogenesis of bioengineered teeth from the cervical-loop structure of rat incisors in vivo.

2. The goals of this study were to examine how DMP1 controls dentin mineralization and odontogenesis in vivo.

3. Some of the same epithelial signals that trigger initiation of odontogenesis also regulate an important category of genes in the jaw mesenchyme .

4. Unfortunately, many years of experiments have established that embryonic epithelium contains a unique set of signals for odontogenesis that disappear from the mouth after birth.

5. Dentin matrix protein 1 (DMP1) is expressed in both pulp and odontoblast cells and deletion of the Dmp1 gene leads to defects in odontogenesis and mineralization.