1 Objective : To explore novel strategy for soman antidote by chemical immunization.

2 Quantum chemical parameters of soman and other organophosphorus esters were calculated by using the CNDO/2 method.

3 The results indicated that the inhibitory effect of Soman on the medullary respiratory centre was much stronger than that of Sarin , while VX was the weakest of three inhibitors.

4 Objective : To explore strategy for soman antidote by chemical immunization.

5 CONCLUSION: Nimodipine might alter the distribution of soman and reduce the initial concentration of soman in rabbit blood, then accelerated the metabolic detoxication of soman.

6 Nerve agents such as Sarin, Tabun and Soman are parts of organic phosphorus esters to which organophosphorus pesticide belong.

7 To know the abzyme mechanism of soman hydrolysis, the structure-activity relationship of soman and abzyme was studied.

8 Results: The synthesized antigen induced catalytic antibodies with high efficiency in catalyzing hydrolysis of nerve agent soman and a novel phospho -transesterification reaction was discovered.

9 Objective: To observe the neurotoxicity of hypoxia at high altitude in combination with soman intoxication .

10 AIM To study the relationship between the capability of soman detoxification of blood and the detoxifying enzyme activities in blood of different species.

11 Methods The ways of skin injury of ultraviolet radiation skin permeation of soman and section of skin tissues were used for the study.

12 Methods Experimental Wistar rats were randomly divided to four groups:normal control gro up, high altitude hypoxia group, plain soman intoxication group and soman intoxication combined hypoxia group.

13 These results indicate that the anaerobic VX-metabolizing enzyme is different from soman and paraoxon hydrolases.

14 Objective: To explore the role of calcium in the injury of nerve cells induced by soman intoxication and its mechanism.

15 After subcutaneous administration , the concentration of C ( ± ) P ( - ) soman was determined by using DFP as internal standard.

16 Objective To explore the roles of muscarinic acetylcholine receptor (M receptor) in rat brain injuries after soman intoxication combined with hypoxia.

17 Methods Experimental Wistar rats were randomly divided into four groups:normal control group, high altitude hypoxia group, plain soman intoxication group and soman intoxication combined hypoxia group.

18 Objective To study the change in inhibitory G protein of rat myocardium after hypoxia combined with soman intoxication so as to provide theoretical basis for clinical therapy.

19 Methods Experimental Wistar rats were randomly divided into four groups: normal control group, soman intoxication group, and hypoxia combined soman intoxication group.

20 Nerve Gas - the world's first three types of "Nerve Gas" chemical weapons were developed in Germany: Tabun (1936), Sarin (1938), Soman (1944), all many times more lethal than earlier chemical weapons.

21 As CNS lesions were closely correlated with convulsions, anticonvulsants must be used after soman poisoning.

22 Objective: To observe the changes of the activity of catecholamine neuron groups in the brain stem after acute soman intoxication.