1. Histone is vitally important for survival.

2. But the histone H4 document hasn't just been copied, it has been subjected to natural selection.

3. The histone code will not be easy to crack.

4. Histone modifications are implicated in influencing gene expression.

5. In the histone code the methylation target is known as H 3 K 9, where K stands for lysine.

6. Histone H3 is one of the four histones, along with H2A, H2B, and H4, which form the eukaryotic nucleosome octamer core.

7. SATB 1 also globally regulates histone status in the chromatin by recruiting histone - modifying enzymes to the target - loci.

8. Arginine An AMINO ACID found especially in the histone proteins that surround DNA in chromosomes.

9. The chromatin remodeling and histone acetylation were associated with transcription activation.

10. Contrast to HMG histone H1 showed obvious inhibition effect on transcriptional activity of all of the rat liver nuclei.

11. The pharmacological actions histone deacetylase inhibitors and their potential clinical uses were reviewed.

12. The level of histone acetylation plays an important role in progression, proliferation and differentiation of leukemia.

13. To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants tails.

14. These alterations in the histone code may alter gene expression pattern to set the stage for leukemogenesis.

15. Histone deacetylases (HDACs) participates in composition ofa transcriptional corepressor complex to exert regulatory roles for kinds of tumor suppressor genes.

16. Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs.

17. In addition, histone exchange reveals new changing mechanism of DNA - histone interaction.

18. Chicken liver chromatin component DNA : RNA : histone: non - histone ratio is 1∶0.

19. SET domain proteins contain conserved SET domains, which intensively involved in histone methylation.

20. The H3.3A gene may be required to provide postmeiotic histone H3.3 in the male germ line in transition to chromatin packaging in sperm.

21. Z associates with functional regulatory elements, and CTCF marks boundaries of histone methylation domains.

22. As a epigenetic mark for the centromeric chromatin, CENP-A is a histone H3-like protein specific to centromeres.

23. Scientists also suspect that the compounds responsible for this insight, called histone deacetylase inhibitors, could significantly slow memory loss—perhaps for years.

24. In this study, we have identified and characterized a histone H2A variant h2af1o in fish, and revealed its oocyte-specific expression pattern during oogenesis and embryogenesis.

25. Objective To investigate the effects of curcumin on the acetylation of histone H3, P53 and the proliferation of NB4 cells.

26. SET07 is highly identical to H4-K20. Conclusion:The results suggest that SET07 functions as a histone methyltransferase which plays an important role in the life cycle of cells and carcinogenesis.

27. In prokaryotes the nuclear material is simply a circular strand of DNA, not complexed with histone proteins, and cell division is amitotic.

27.

28. The core consists of 140 base pair of DNA wrapped around a globular histone bead containing two each of histones H2A, H2B, H3 and H4.

29. A small molecule called an acetyl group attaches to a particular histone known as H4.

30. The level of his - tone acetylation is determined by the activities of histone acetyltransferases and histone deacetylases.

31. Typical patterns of histone methylations exhibited at promoters , insulators, enhancers, and transcribed regions are identified.

32. Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation.

33. Dr. Fischer’s research shows that when young mice are learning, an acetyl group binds to a particular point on the histone protein.

34. In eukaryotic cells, the fundamental unit of chromatin is nucleosome, which is composed of a histone octamer with two copies of HA, HB, H and H and base pairs of DNA.

35. The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other, which are histone transacetylase and histone deacetylase.

36. DNA remains tightly wound around the histone spool, so the genes on the spool that control memory formation remain suppressed.

37. Chromosome banding patterns are correlated with unique patterns of histone modifications.