1. He has terminal lung cancer.

2. Smoking predisposes you to lung cancer.

3. Smokers face an increased risk of developing lung cancer.

4. Smoking can lead to lung cancer.

5. It's a well-known fact that smoking can cause lung cancer.

6. Smoking is one of the chief causes of lung cancer.

7. There's a high correlation between smoking and lung cancer.

8. Does smoking contribute to lung cancer?

9. Smoking can cause lung cancer.

10. He was diagnosed with inoperable lung cancer.

11. Lung cancer killed his father.

12. Mortality from lung cancer is still increasing.

13. Cigarette smoking has been associated with lung cancer.

14. Is there a connection between smoking and lung cancer?

14. is a sentence dictionary, on which you can find nice sentences for a large number of words.

15. Doctors say passive smoking has caused his lung cancer.

16. Smoking is responsible for many cases of lung cancer.

17. Smoking is a contributory factor in lung cancer.

18. Scientists have established the relationship between lung cancer and smoking.

19. It's a fact that most deaths from lung cancer are caused by smoking.

20. Smoking causes lung cancer.

21. There is an acknowledged risk of lung cancer from radon.

22. She was studying lung cancer, as distinct from other types of cancer.

23. Cigarette smoking is the single most important cause of lung cancer.

24. Many countries have limited or banned the use of asbestos because of fears that its fibres cause diseases such as lung cancer if.

25. It's ironic that her husband smoked for thirty years, and yet she's the one who died of lung cancer.

26. Smoking is known to increase a person's risk of developing lung cancer.

27. Smoking is a causative factor in the development of several serious diseases, including lung cancer.

28. Sir Richard Doll, the epidemiologist who discovered the link between smoking and lung cancer in the 1960s, will this week warn that children living near electricity power lines are at an increased risk from leukaemia.

29. Many countries have limited or banned the use of asbestos because of fears that its fibres cause diseases such as lung cancer if inhaled.

30. Cigarette smoking is responsible for about 90% of deaths from lung cancer.

1. He has terminal lung cancer.

2. Smoking predisposes you to lung cancer.

3. Smokers face an increased risk of developing lung cancer.

4. Smoking can lead to lung cancer.

5. It's a well-known fact that smoking can cause lung cancer.

6. Many countries have limited or banned the use of asbestos because of fears that its fibres cause diseases such as lung cancer if.

31. The test should identify which smokers are most prone to develop lung cancer.

32. Some people still claim that there is no firm evidence linking smoking with lung cancer.

33. Lung cancer is the most commonly found cancer in men.

34. Once diagnosed with lung cancer, a patient is lucky to survive for five years.

35. It can be hard for even a trained doctor to spot the symptoms of lung cancer.

36. There is a direct link/connection between smoking and lung cancer.

37. It causes heart disease, lung cancer, bronchitis and emphysema.

38. Any lung cancer that has spread is considered incurable.

39. A radon-related excess of lung cancer is well established.

40. Payton's premature death was caused by lung cancer.

41. Is chemotherapy for non-small cell lung cancer worthwhile?

42. And it tends to spread quickly; only 13 percent of lung cancer patients survive five years.

43. A typical example is the tendency to blame yourself for instance, for smoking for many years before developing lung cancer.

44. Specialist medical evidence in the case showed that he had developed lung cancer as a result of active and passive smoking.

44. is a sentence dictionary, on which you can find nice sentences for a large number of words.

45. There was no evidence in these miners that a radon-rich atmosphere increased the risk of any cancer other than lung cancer.

46. This means that several hundred of the 40,000 deaths from lung cancer each year may be caused by passive smoking.

47. But the point is that lung cancer is immediately connected with smoking, in everybody's mind.

48. The relationship between smoking and lung cancer is a classic study from the field of epidemiology.

49. Ivester, 50, had been considered heir apparent to replace Goizueta, who died Saturday from complications related to lung cancer.

50. However, mortality from lung cancer increased significantly over this period.

51. His first wife Joy was a heavy smoker who died of lung cancer.

52. Lung cancer deaths have halved since 1965, mainly due to a reduction in the number of people who smoke.

53. She died of lung cancer, a result of a three-decade smoking addiction.

54. It is directly responsible for 35,000 deaths from lung cancer and twice this number from other diseases every year.

55. He has claimed success with every kind of tumour that he has treated - including lung cancer at a late stage.

56. Approximately 90% of deaths from lung cancer and bronchitis are caused by smoking.

57. The higher rate of smoking among men, causing lung cancer and much heart disease, may Partly explain the differential.

58. Breast cancer is second only to lung cancer in U.S. cancer-related deaths.

59. Smoking Smoking is linked both to lung cancer and coronary heart disease.

60. One area of recent debate concerns radon gas and its links to lung cancer.

61. Lung cancer, for example, is caused by the substances that accompany nicotine in tobacco smoke, not by nicotine itself.

62. They say giving some one a patch is far cheaper than treating the same person for heart disease or lung cancer.

63. I still remember the heartbreak of watching my dad suffer from lung cancer.

64. A five-year survival rate in lung cancer is still less than ten percent.

65. Sue never smoked a cigarette in her life, yet she still got lung cancer.

66. The human psyche is so pathetically insecure that we would rather die of lung cancer than confront an uncomfortable situation.

67. There was a risk that he could develop mesothelioma or lung cancer.

68. Recent studies have found an increased risk of diseases other than lung cancer in passive smokers.

69. For the older age groups there is a distinct gender difference in the importance of lung cancer as a cause of death.

70. There is a rare form of lung cancer, distinguishable from the usual type only under the microscope.

71. Lung cancer Lung cancer kills more people than any other type of cancer and 90% of these deaths are caused by smoking.

72. Lung cancer accounts for 15 percent of female cancer deaths.

73. Eventually the chances of developing lung cancer and other diseases will also be lessened, until they are the same as for non-smokers.

74. If this were so, giving up smoking would not alter an individual's chance of developing lung cancer.

74. is a online sentence dictionary, on which you can find nice sentences for a large number of words.

75. Lung cancer is one of the more aggressive and tenacious forms of cancer.

76. Williams died today after a long battle with lung cancer.

77. There is a demonstrable link between smoking and lung cancer.

78. But in terms of years of potential life lost, the biggest killer is lung cancer, which usually strikes in middle age.

79. Other factors can cause lung cancer but they are much less important than smoking.

80. It accused Roy of using his very public fight to beat lung cancer as a way of furthering his career.

81. Heart attacks and lung cancer are directly linked with cigarette smoking.

82. The number of people dying from lung cancer has increased at an alarming rate.

83. One of lung cancer's success stories, he runs a support group for lung cancer patients and their families.

84. Lung cancer was not seen as a sequel to smoking until the middle of the twentieth.

85. I might ignore all the warnings and even try to convince other people that lung cancer does not really exist.

86. The younger a person is when he or she starts smoking, the greater the risk of developing lung cancer.

87. Mesothelioma and lung cancer are very different diseases.

88. Lung cancer deprived him of his life.

89. Pathology report: brain tumor, lung cancer cells.

90. Nonsmoker Lung Cancer: A Different Disease?

91. Objective To investigate the value of X-ray Knife in the stereotaxis radiotherapy of lung cancer.

92. The other case of lung cancer with complicating chylothorax was published in Poland, and reported that the leakage of chyle into the pleural cavity could be stopped after chemo- and radiotherapy.

93. Conclusion Antisense ERCC1 RNA decreased the repair capability for damaged DNA in lung cancer cells induced by benzopyrene.

94. Methods The expression of SEMA3B was detected in 52 human lung cancer tissues and paired 52 non cancer tissues by To explore the relationship between SEMA3B gene expression and onc RT PCR.

95. Large cell neuroendocrine lung cancer ( LCNEC ) is the rare subtype of non - small cell lung cancer.

96. Method:This research use prospective method, which is performed on 60 lung cancer patients from the tumor inpatient department who are choiced accord to the observation condition.

97. WG was usually misdiagnosed as primary lung cancer or metastasis while MPA was usually misdiagnosed as lung infection and interstitial pneumonia.

98. Computer-aided diagnosis (CAD) plays an active role in improving the diagnostic accuracy, popularizing exams, and reducing the missed lung cancer.

99. Methods Analysed CT appearance of 14 lung cancer cases which appeared cave with thin wall and 9 cases which was being cystoid completely or mostly , and compared to their foundation of pathology.

100. Methods: 56 patients with lung cancer were treated with CVAD and CCE regimen.

101. The study found that non-smoking wives of men who smoke cigarettes face a much greater than normal danger of developing lung cancer.

102. House determines she has lung cancer or tuberous sclerosis, and tries to order a biopsy.

103. OBJECTIVE: To screen genes differentially expressed in two human giant-cell lung cancer lines of same origin but with different metastasis potentials.

104. Curtis must get chemotherapy once every two weeks for his lung cancer.

105. Methods Platelet count in 112 patents with lung cancer was analyzed.

106. But about half of cases of never-smokers with lung cancer cannot be explained by known risk factors, which also include asbestos, indoor wood-burning stoves,[] and aerosolized oils caused by cooking.

107. A morally ambiguous confidence man who smokes, has lung cancer and is tormented by the spirits of the undead. Well, if that doesn't make me the favorite aunt, I don't know what will.

108. Objective To improve the diagnosis and differentiation by imaging analysis of tuberculoma and peripheral lung cancer.

109. Blood in phlegm can be a sign of lung cancer.

110. Lung cancer is a familiar malignancy currently, the nosogenesis is very complex.

111. But the only patients in the trial will be from the 5 percent or so of lung cancer patients with a mutation in a gene called A.L.K.

112. The change in smoking is paralleled by a change in the incidence of lung cancer.

113. In addition, researchers found that the IGS was also predictive of clinical outcomes in individuals with prostate cancer, lung cancer and medulloblastoma.

114. Objective:To study the efficacy of Elemene in combination chemotherapy of lung cancer.

115. Results: Of the 68 patients with lung cancer, 24 patients (35.3%) were identified with supraclavicular lymph node metastasis.

116. There were 13 cases of pulmonary arterioplasty with sleeve lobectomy, including 11 cases of lung cancer.

117. Yuan said testing for NNAL and cotinine in urine may serve as a starting point for a new way of predicting lung cancer risk.

118. Results:24patients with SPLC were found in2223patients with lung cancer receiving the surgical therapies. SPLC were synchronous with primary tumor in11cases and metachronous in13cases.

119. diagnosis of lung cancer.

120. Could Lung Cancer Patients without Accurate Pathological Diagnosis Get the Anticancer Treatment?

121. METHODS: Cell line A549 and GLC-82 originated from human non-small cell lung cancer were cultured in vitro. Study group (2-ME in different concentrations) and control group without 2-ME were set up.

122. Conclusion The feature of mediastinal lymph node metastases in lung cancer may be saltatory and multiple.

123. Because after 10 years without smoking, the risk of lung cancer is similar to that of a nonsmoker.

124. The biotherapy of lung cancer developed quickly, especially the molecule targeted therapy, which had achieved graveness progression and the curative effect was striking.

125. Mesothelioma is a from of lung cancer that is almost always caused by asbestos exposure and is most commonly found in the outer lining of the lungs called the mesothelium .

126. Objective To investigate the inhibition effect of Limax extract(LE) in the growth of human lung cancer A549 cell line in vitro and tumorigenicity in mice.

127. Conclusion The modified restriction enzyme-based method is convenient for clinical EGFR mutation screening in non-small cell lung cancer for its simpleness, cost-saving and high sensitivity.

128. Conclusions CT guided TCNB is a safe, reliable method with high accuracy in diagnosis and less complications, especially for non lung cancer malignancy and benign lesions.

129. Objective To determine the usefulness of positron emission tomography(PET) with fluoro 2 deoxyglucose (FDG PET) in lung cancer.

130. Methods: The sputa of 30 lung cancer patients and 25 benign lung disease patients(control group) were checked for telomerase activity with PCR-TRAP ELISA.

131. Small cell lung cancer is neuroendocrine neoplasm and origins from APUD ( amine precursor uptake decarboxylation ) cell.

132. Researchers say true up ( about ) to 30 % of Amercan women who develop lung cancer.

133. Objective To evaluate the clinical effect of stereotactic radiotherapy in the treatment of lung cancer with superior vena cava syndrome.

134. Objective The main aim of this study is to look for early surveillant biomarkers of lung cancer among workers exposed to coke oven emissions (COE).

134. try its best to gather and build good sentences.

135. The group of advanced lung cancer also showed the increased metabolism in thalamus and basal ganglion.

136. Objective:To explore the reasons, the preventions and the treatment for the cardiac arrhythmia after the lung cancer operation.

137. Objective To discuss the diagnostic value of detecting sulfate glycosaminoglycan fragments (SGF) in non-small cell lung cancer (NSCLC).

138. In asbestosis patients, lung cancer must be differentiated from benign fibrotic masses and rounded atelectasis.

139. Methods The Single radial immunodiffusion method was used to detect IAP in 65 cases of lung cancer, 15 cases of benign lung diseases and 30 normal controls.

140. Objective To analyse the CT appearance of lung cancer which appeared cave with thin wall or cystoid and their foundation of pathology.

141. Last week, Dana Reeve died of lung cancer at the age of forty - four.

142. Effect such as brain tumor , cervical cancer, lung cancer, cancer of the stomach, neuroblastoma intestinal cancer.

143. Objective To explore the relation between HPV infection and lung cancer in female nonsmoker, and to investigate its relationship with LOH of FHIT gene.

144. Methods 24 fresh lung cancer specimens were detected by FISH with the centromeric probes of chromosome 8,11,12 and 17.

145. CD4 count was the only risk factor for Hodgkin's lymphoma, lung cancer and liver cancer, the study found.

146. Objective: To evaluate the relation between serum immunosuppressive acid protein (IAP) content and occurrence of lung cancer.

147. Results The main proportional mortality was pneumocardial disease (36.18%), pulmonary tuberculosis (21.05%) and lung cancer (11.84%).

148. Conclusions Osseous metastasis in lung cancer is characterized by multiple osteolytic damage.

149. Objective:To investigate the efficacy and safety of combinativechemotherapy with mitomycin(MMC), vindesine(VDS) and cisplatin(DDP) in patients with advanced non-small cell lung cancer(NSCLC).

150. Results Some functional imaging characteristics exist between tuberculoma and peripheral lung cancer.

151. To investigate the clinical significance of the spermidine content in urine as an index of accessory diagnosis, prognosis and therapeutic effect evaluation for patients with lung cancer.

152. A statistically significant excess in lung cancer mortality occurred in immigrants age 45 to 64.

153. Objective To lengthen the survival time and improve the QOL of the patients of Non-small Cell Lung Cancer(NSCLC) with carcinomatous pleuritis by the new surgical treatment strategy we have developed.

154. Results According our statistic result, there were about 35 - 41 % thrombocytosis in patients with lung cancer.

155. Conclusion BAI and BACE with sandwich method is one of the most effective therapies for the treatment of advanced lung cancer.

156. Benzopyrene (B(a)P) and coal-tar pitch (CTP) are one of the important factors of enhancing incidence and mortality in the taroperating population with professional lung cancer.

157. Just then a doctor came with the result of the medical exam of the manager, saying the manager was suffering a Lung cancer.

158. Objective To observe short term therapeutic effect of catheterization of bronchial artery to perfuse CD3AK in the treatment of medium and advanced lung cancer.

159. In May, Donaldson and colleagues reported in Nature Nanotechnology that carbon nanotubes, tiny needle-shaped fibres of carbon, can lead to a form of lung cancer caused by asbestos in mice.

160. Conclusions The palliative operation with video-assisted thoracoscope can improve life quality and prolong survival time effectively in combined therapy for late lung cancer.

161. The authors have discussed the differential diagnosis of this disease, lung cancer, tuberculoma and hamartoma.

162. For instance, lung cancer was mostly an inherited disease until people starting smoking, and then it became a disease that was caused mostly by cigarettes.

163. MRI in showing lung door and mediastinum lymph gland has important value to shift, which has important direct significance in diagnosing lung cancer by stages and operation.

164. Conclusion It shows that treatment of advanced lung cancer with VLB and DDP by bronchial arterial infusion has a higher response rate and tolerable toxicity.

164. is a sentence dictionary, on which you can find good sentences for a large number of words.

165. Purpose To evaluate some specific MR findings used to differentiate the lung cancer and benign tumor.

166. Objective To review surgical experience in the treatment of non small cell lung cancer by lobectomy with pulmonary arterioplasty and to study feasibility of this approach.

167. Objective:To explore the mechanism of coagulable abnormality and the effect of anticoagulation on prognosis in advanced cases of lung cancer.

168. Methods The characteristic imaging findings of 100 patients on X-ray and CT diagnosed extrapulmonary metastases of lung cancer were analyzed.

169. The drug, aurothiomalate, is being tested in a phase I clinical trial in patients with lung cancer at Mayo Clinic's sites in Minnesota and Arizona.

170. Radon can cause lung cancer, leukemia, albinism and other pathological changes in respiratory tract.

171. ObjectiveTo study the clinical manifestation of lung cancer complicated by hospital acquired pneumonia, pathogen and its drug-fast strains to provide applicable clinical evidence.

172. Methods Pathogenic bacteria species were determined and drug sensitive tests were conducted for 31 lung cancer patients who have got infection in lower respiratory tract after chemotherapy.

173. Three sharp cedar ester alkali has remarkable curative effect for treating carcinoma oesophagi, stomach cancer, rectal cancer, lung cancer, leukemia, the lymph lattice cytoma, the lymphosarcoma.

174. METHOD: There were 73 patients with central-type lung cancer underwent sleeve lobectomy trachea-bronchoplasty whose clinical data were retrospectively analyzed.

175. Chromium, a corrosion-resistant material, is used in stainless steel, paints, dyes and the tanning of leather which can cause lung cancer in people who work in industries where it is commonly used.

176. Objective To analyze the short-term effects and long term survival of patients with lung cancer underwent tracheal carina reconstruction and bronchoplasty.

177. Last august, dinnerwev announced that she had lung cancer. Smoking is linked to 90 percent of cases, but dinner wive did not smoke.

178. Lung cancer has now overtaken breast cancer as a cause of death for women in the US.

179. Mao's team wanted to find a way to monitor patients taking a drug -- the COX-2 inhibitor celecoxib, sold by Pfizer under the brand name Celebrex -- in the hopes of preventing lung cancer.

180. It was dected that andrographolide had the action of anti-tumor in gastric cancer, liver cancer, lung cancer and breast cancer.

181. End-of-life care for older people with advanced lung cancer differs in the United States and in the Canadian province of Ontario, a new study says.

182. The residence gradient for lung cancer was strongest among nonsmokers.

183. CT scanning has high sensitivity and specificity to detect early lung cancer.

184. Silibinin, a drug derived from milk thistle, destroys lung cancer in mice, investigators at the University of Colorado, Denver report in the Journal of the National Cancer Institute.

185. Stratified by sex, age, history of smoking and pathology: male, age between 40 and 70 and without smoking carrying with G/C or G/G will have decreased susceptibility to lung cancer.

186. Methods: Lobectomy and pneumonectomy via intrapericardial management or combined with partial resection of left atrium were carried out in 141 patients with lung cancer.

187. Iraq's most powerful Shiite leader Abdul Aziz al-Hakim died of lung cancer at a hospital in Tehran, Iraqi official television reported Wednesday.

188. Objective To investigate the extrapulmonary metastatic mechanism of lung cancer and its correlation with X-ray findings.

189. Purpose To investigate the clinical value of serum neuron specific enolase ( NSE ) in lung cancer.

190. The automatic segmentation of lung parenchyma is one of the key techniques to the computer-aided diagnosis (CAD) system for lung cancer, emphysema and other lung diseases.

191. Objective To summarize the clinical results of intrapericardial ligation of pulmonary vessels in the treatment of central type lung cancer.

192. AIM To review the experience in the surgical treatment of central lung cancer with bronchoplsty and pulmonary arterioplasty.

193. The female contracts the lung cancer is to a great extent the passive smoking causes.

194. The geographic distribution of lung cancer was dissimilar to that of industrialization.

194. Wish you can benefit from our online sentence dictionary and make progress every day!

195. Patient of cellule lung cancer, after art 1 year, spend 6 months after cure, can you do now excuse me preventive change cure?

196. EGFR tyrosine kinase inhibitor is an investigative hot spot in targeted therapy of non-small cell lung cancer(NSCLC).

197. One is through for reduced productivity fortuity among workers who to get lung cancer or other tobacco-related diseases.

198. Objective: In investigation and discussion, the later period lung cancer patient applies traditional Chinese medicine preparation, the laxation effect changing to tumour.

199. OBJECTIVE : To study the in vitro sensitivity of lung cancer tissue to commonly antineoplastic ˉ tics.

200. For a smoker to talk about lung cancer is to look one way and row another.

201. Objective To study the change law of TCM syndromes before and after the treatment of non-small cell lung cancer with cryotherapy of argon-helium superconductive operation system.

202. The immigrant does not experience the lung cancer rate prevalent in his country of settlement.

203. These are likely to be typical of the early symptoms of lung cancer.

204. Elevated serum AKP level is helpful for the diagnosis of osseous metastases of lung cancer.

205. Objective: To evaluate the effect of combined Cisplatin Sustained Release for Implant with radioactive iodine-125(125I) to non-small cell lung cancer(NSCLC) guided by CT.

206. Secondary affection of lung cancer would help to differentiate benign and malignant lung tumor.

207. Recent evidence suggests that Tob could be a tumor suppressor gene in lung cancer.

208. The transfection efficiency was influenced by different incubate time between ESCORT - DNA mixture and lung cancer cells.

209. Results of this study, which were presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer, support ongoing Phase III studies of ASA404 in NSCLC.

210. Methods The clinical data of 55 patients with central lung cancer undergoing intrapericardial pneumonectomy from 1990 to 2002 were retrospectively analyzed.

211. Objective To explore the correlation between bronchial arteriography ( BAG ) and pathological types of lung cancer.

212. Objecitve To evaluate the benefits of three methods of extracorporeal vein bypass from superior vena cava (SVC) to femoral vein during lobectomy and SVC graft in patients with lung cancer.

213. We should give greater attention to indoor and occupational exposure of lung cancer victims.

214. To study the association between TLR 9 gene polymorphism and lung cancer susceptibility.

215. "Pistachios are a good source of gamma-tocopherol. Eating them increases intake of gamma-tocopherol so pistachios may help to decrease lung cancer risk, " she said.

216. This is the first, and, to date, only trial of an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to show a survival advantage for patients with advanced non-small cell lung cancer.

217. The result does not exclude the possible coexistence of an underlying lung cancer.

218. Bronchoplasty and pulmonary artery reconstruction extended the surgical indications for lung cancer, which reveal farthest excision of pulmonary tumor and farthest preservation of normal lung tissues.

219. There are other differences between lung cancer and mesothelioma as well.

220. This article review recent advances of lung cancer biotherapy and biochemotherapy, including molecule targeted therapy and gene modified dendritic cell therapy.

221. It is because of the proximity of the pleurae to the lung that many people mistakenly think of pleural mesothelioma as a form of lung cancer.

222. Objective To evaluate the immunotherapeutic application of tumor-associated melanoma antigen gene(MAGE) -1, and-3 as the targets for lung cancer immunotherapy .

223. Objective To evaluate therapeutic effects and toxicity of advanced non-small cell lung cancer (NSCLC)treated by combining chemotherapy on ifosfamide(IFO)and vinorelbine(NVB).

224. Methods perfusion into bronchial artery in interventional treatment of lung cancer was carried out.

225. The effects of HFE on lung cancer cell YTLMC-90 were proceeded by means of three assays as follows: Methyl thiazolyl tetrazolium (MTT) assay, cell double time analysis and colony forming assay.

226. Fortunately, worried smokers can already get themselves checked out for possible lung cancer, and might even consider using electronic cigs to kick the habit.

227. Objective To assess diagnostic value of thrombocytosis through observing platelet count in patients with lung cancer.

228. Results 30 lung cancer patients all appeared much or system bone metastasis.

229. Navebine is a new semi-synthetic cytotoxic drug. Distinctive anticancer activity was observed in the treatment of 32 patients with non-small cell lung cancer.

230. Objective: A correlative study of VEGF value of blood-serum of patients with lung cancer and tongue images of traditional Chinese medicine.

231. Objective To evaluate the efficacies of radiochemotherapy(RCT) alone and RCT plus pretreatment with amifostine on local advanced non-small-cell lung cancer(NSCLC) and their side effects.

232. The genetics underpinning a smoker's risk of developing lung cancer have been further unpicked by UK scientists.

233. This article reports the experiences in doing intrapericardial pneumonectomy in 24 patients with lung cancer.

234. OBJECTIVE:To define the activity and toxicity of teniposide in combination with cisplatin in treatment of lung cancer.