1) OBJECTIVE To choose the best formulation of sinomenine gel.

2) Objective:Sinomenine, a alkaloid monomer extracting from a plant Sinomenium acutum, has been used to relieve rheumatoid arthritis in human having well therapeutic effect and a few side effect.

3) The therapeutic effect of sinomenine on rheumatoid arthritis may be related to its inhibition to secretion of IL-12 in DCs.

4) AIM: The transdermal absorption data of sinomenine patch was fitted by grey model GM(1,1) and compared with other models.

5) OBJECTIVE The relative bioavailabilities of different sinomenine hydrochloride crystal in healthy volunteers were compared.

6) Results: In the naloxone-precipitated tests, after injecting sinomenine for 10 days continuously, the mice and rats didn't show any withdrawal symptom and the loss of body weight.

7) OBJECTIVE:To establish a method for the determination of sinomenine in Bitongding capsules by HPLC.

8) Objective:To study immune inhibitory effect of Sinomenine(SIN)and provide experimental gist for application of SIN in organic transplantation.

9) Objective To compare the relative bioavailabilities of different sinomenine hydrochloride crystal in healthy volunteers.

10) Objective:To study the pharmacological action of sinomenine on chronic nephritis.

11) Methods Single-chamber diffusion cell was used and sinomenine concentration was determined by HPLC in vitro.

12) Objective: To prepare sinomenine gel and study its skin penetration in vitro.

13) Conclusi on The mechanism of curative effect of sinomenine on arthritis concern with rising the level of apoptosis.

14) To explore the feasibility and advantages of blood microdialysis technique for the pharmacokinetic study of sinomenine.

15) Methods: The membranous glomerulonephritis rabbit model was induced by cationized bovine serum albumin (C-BSA) and then treated with sinomenine.

16) Methods:Orthogonal tests were employed for optimum of extraction technology,(http:///sinomenine.html) the determination of the contents of Chlorogenic acid and Sinomenine were gained by HPLC and TLC-scanning respectively.

17) Result:There were significant effects on acute and chronic and adjuvant arthritis in rats with sinomenine gels.

18) Yale University is the history of the United States on the establishment of a third university, this Sinomenine longer a member of the Union.

19) CONCLUSION: The combination drug therapy for treatment of rheumatoid arthritis in comparision with sinomenine singlely there is high efficacy and the lower rates of adverse reaction.

20) The hypnotic action of thiopental in mice was not prolonged by Sinomenine.

21) OBJECTIVE:To develop a preparation and quality control method for sinomenine gel.