1, Water restriction would lead to more obvious hypertonicity.

2, Gradually developing hypertonicity produces less symptoms than that developing abruptly.

3, The sequelae of hypertonicity are believed to result largely from changes in brain cell size.

4, Hypertonicity may also result from pure sodium excess, although this is relatively uncommon.

5, The specific treatment of hypertonicity depends upon the inciting cause.

6, Although hypertonicity may develop from extrarenal causes alone, more frequently hypertonicity results from interference with the formation of a concentrated urine.

7, If age, weakness, or intercurrent illness prevents adequate fluid intake, then severe hypertonicity may result.

8, HOCM can induce cultured HKC cells apoptosis, which is related to the hypertonicity and iodine concentration of contrast media.

9, Botulinum A toxin has been widely applied to the treatment of muscular hypertonicity for many different functional systems of the human body.