1. Association of a purine-analogue-sensitive protein kinase activity with p75 nerve growth factor receptors.

2. Jun-Core is phosphorylated by a DNA-dependent kinase in HeLa nuclear extracts.

3. The site, or sites, at which protein kinase C exerts these inhibitory effects is unresolved.

4. I calculated how much kinase I had missed earlier and then just made up for it.

5. Sunitinb is a novel multitargeted receptor tyrosine kinase inhibitor.

6. Methods: Activity was assessed with kinase activity assay.

7. Is PDGF tyrosine kinase inhibitor effective in pancreatic cancer?

8. PTK787 is the most promising VEGF receptor- tyrosine kinase inhibitor in pipeline because of its potency in tumor inhibition and oral bioavailability.

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9. CONCLUSION(Kaempferol is a) novel potent inhibitor of protein kinase CK2 in vitro.

10. The comparision of homologous sequence about different kinase confirmed that the ATP binding, site of the deoxycytidine kinase is in the N-terminal region.

11. Summary of Background Data. The stress-activated mitogen-activated protein kinase pathways including ASK1 transmitted apoptosis signals after acute spinal cord injury.

12. Conclusion: Our study indicates that JAK kinase can affect the activity of ERK signal transduction pathway through the phosphorylation of ERK.

13. Protein kinase C was partially purified from rat liver by homogenization, ammonium sulfate fractionation and DEAE-cellulose chromatography.

14. Here we investigated whether integrin - linked kinase ( ILK ) may regulate LV remodeling and function after myocardial infarction.

15. Objective To investigate the correlation between phosphatidylinositol 3 kinase (PI3-kinase) and the pathogenesis of psoriasis.

16. The mitogen-activated protein kinase (MAPK) cascade plays an important role in signal conversion and amplification of extracellular stimuli in eukaryotic organisms.

17. Out of 16 cases that tested positive for creatine kinase, nine were confirmed, giving an incidence of 1:3082 births.

18. Both of these non-conserved amino-acid substitutions would have highly detrimental effects on the catalytic function of the putative protein-tyrosine kinase.

19. Until the results of long term follow up are available the ability of our creatine kinase assay to detect Becker cases remains uncertain.

20. Subjects - Those families whose son had a positive screening test. Main outcome measures - Creatine kinase activity.

21. Thus(), both of the point mutations characterized here would be expected to eliminate kinase activity of the proposed atk protein product.

22. This study was to search specific CK2 inhibitors in tumor cells through observation of the inhibitory effects of baicalein on recombinant human protein kinase CK2 holoenzyme and its kinetics in vitro.

23. Measurement of activities of key enzymes in respiratory pathways showed that the activities of pyruvate kinase and malate dehydrogenase were higher in blue light treatment.

24. Enter AICAR, which targets a protein called adenosine monophosphate - activated protein kinase ( AMPK ).

25. Genistein is a high specific and noncompetitive inhibitor of epidermal growth factor receptor tyramine kinase domain(EGFR-TK).

26. Cell cycle in plants is controlled byactivity of cyclin - dependent kinase ( CDK ) complexes.

27. Rapamycin arrested cell cycle in G 1 phase to antitumor by degrading the CDK - cyclin complexes kinase activity.

28. Deoxyribozymes have some catalytic functions, such as RNA transesterification, DNA transesterification, porphyrin metalation, peroxidase activity, DNA kinase activity and DNA ligase activity.

29. All these actions VEGF are mediated by receptor tyrosine kinase , vascular endothelial growth factor receptor ( VEGFR ).

30. Objective To study the effect of CARK, a cardiac specific kinase, on cardiac hypertrophy.

31. In the sporophytic SI system of the cabbage family, the S gene is actually two linked loci, one producing a glycoprotein and the other a receptor kinase.

32. Extracellular signal - regulated kinase ( ERK ) signaling pathway is a critical signaling pathway that transduce the intracellular signal.

33. The inhibitory effects of JAK kinase on MMP-9 expression and invasion of breast cancer cells are associated with the blocking of the ERK signaling pathway.

34. Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter?

35. Genistein, the tyrosine kinase inhibitors, plays the effect by an inhibition of tyrosine phosphorylation.

36. MethodsThe supporter paper fiber was activated with epoxy chloropropane etc. According to the influence of spacer and different ligand on absorption of kinase, process route was optimized.

37. While the C-terminal of the choline kinase contained a phosphotransferase consensus sequence, which was presumed to be involved in catalytic function.

38. A surprisingly low seropositivity rate of anti-acetylcholine-receptor antibodies (1/7) and anti-MuSK (Muscle Specific Kinase) antibodies (0/6) were found in these dysphonia MG patients.

39. Methods The supporter paper fiber was activated with epoxy chloropropane etc. Accordiag to the influence of spacer and different ligand on absorption of kinase, process route was optimized.

40. Myocardial content of hydroxyproline(HP)was detected by test kit, and that of creatine kinase(CK)tested by N- acetylcysteine activation method.

41. Receptor protein kinase ( RPK ) is an important kinase in protein kinase family.

42. This paper reports about preparation and purification of ONA probe related to deoxycytidine kinase gene. The hybridization condition has been explored.

43. Activating mutations in the RET proto-oncogene cause hereditary MTC, which provides a strong therapeutic rationale for targeting RET kinase activity.

44. Pre-treatment with the different specific kinase inhibitors, the activities of AP-1 induced by Ox-LDL were determined by electrophoretic mobility shift assay (EMSA).

45. This change of shape converts the normally inactive kinase into an active one, which then sends signals inside the cell that trigger cell growth.

46. NADH kinase is the critical pathway for NADP (H) biosynthesis in yeast.

47. The three most important candidate drugs currently in development include a glycosaminoglycan, a protein kinase C (PKC) inhibitor and an inhibitor of advanced glycation.

48. Objective To study the expression of phosphoinositide 3 kinase (PI3-K) and its relationship with lung cell apoptosis in rats with acute lung injury induced by oleic acid.

49. Serum isoenzyme(MB) and isoform(MM3) of creatine kinase (CK) were measured in30 patients with acute myocardial infarction (AMI) to assess the reperfusion.

50. The proto-oncogene KIT, a tyrosine kinase that is inhibited by Gleevec, is overexpressed in a majority of GISTs.

51. The protein, known as AMP - activated protein kinase AMPK, controls metabolic decisions of cells.

52. Wortmannin(WT), the specific inhibitor of phosphatidylinositol 3 kinase(PI3K), was used to reflect indirectly the possible involvment of PI3K.

53. Mitogen activated protein (MAP) kinase, also known as extracellular signal regulated kinase, or ERK, functions in neuronal signal transduction and participates in diverse development processes.

54. Titanium pigment, 1398 moderate protein kinase, potassium nitrate, sodium nitrate, inositol, ferrous sulfate, etc.

55. JANEX-1 exhibits significant anti-leukemia activity, which could induce apoptosis in human lymphoblastic as well as myeloblastic leukemia cells with over-expressed tyrosine protein kinase.

56. HNMPA-AM3 -the insulin receptor tyrosine kinase inhibitor could block the anti-apoptosis effect of insulin.

57. The tomato gene in question codes for an enzyme called thymidine kinase.

58. Valsartan, but not hydralazine, prevented neuronal apoptosis, being associated with the suppression of apoptosis signal-regulating kinase 1 activation by valsartan.

59. In terms of the mechanism, an inhibition of two pathways reported to be involved in the development of tumours, namely NF-kappaB and c-Jun N-terminal kinase (JNK).

60. Unnatural amino acid site - directed mutagenesis was applied to adenylate kinase to study its mechanism.

61. They found that the asymmetric activation of one EGFR kinase domain by another is analogous to the activation of cyclin-dependent kinase (CDK) by cyclin, which are involved in regulating cell growth.

62. Objective To investigate the role of protein kinase C(PKC) signal pathway in airway smooth muscle cell(ASMCs) proliferation in asthmatic rats.

63. It is suggests that these signal molecules play a key role as part kinase cascadelinking hematopoietic growth factor receptors to mitogenesis and other cellular responses.

64. The ribR gene in Bacillus subtilis encodes monofunctional flavin kinase, which would convert riboflavin to FMN.

65. Objective: To study the effect of protein kinase C(PKC) on ankyrin in erythrocytes.

66. The assay begins with a standard kinase reaction performed in the provided Reaction Buffer with a provided Bisamide Rhodamine 110 peptide substrate (PKA R110 Substrate).

67. AIM: To investigate the effect of protein kinase C on resistin expression in 3T3-L1 adipocytes.

68. In addition[/kinase.html], monophosphate - activated protein kinase ( AMPK ) levels were high during fasting and low during HF diet.

69. Objective To diagnose and treat leukemia, protein tyrosine kinase (PTK) activities were studied in human blood and myelogenic cell.

70. OBJECTIVE To find the inhibitor of protein kinase CK2 by investigating the direct effect of 3,6-dihydroxyflavone on holoenzyme and its kinetics.

71. Inherited deficiency of pyruvate kinase, a key glycolytic enzyme, causes ATP deficiency, which leads to reduced RBC life span and hemolytic anemia.

72. The present invention relates to the treatment of EGFR-mediated disease, particularly cancer, which is resistant to tyrosine kinase inhibitor therapies.

73. Objective To investigate the relationship between the phorbol 12-myristate 13-acetate (PMA) activated protein kinase C (PKC) and the subcellular expression of TorsinA protein.

74. Being deprived of even one essential amino acid is enough for the GCN2 kinase to switch the metabolism into an emergency mode.

75. Methods Radio-immunity and ELISA were used to dynamically detect the activity of protein tyrosine kinase and phosphatase in the cytoplasm of H22 cells treated by PDT.

76. Objective To observe the relationship between the level of estradiol E2 in serum and activities of cretin kinase (CK), lactate dehydrogenase (LDH) and aspartate transaminase (AST) in rat heart muscle.

77. In the past we relied on creatine kinase or the MB fragment of creatine kinase.

78. When wheat plants allowed to become deficient in potassium, pyruvate kinase activity increased.

79. Objective To investigate the clinical significance of serum creatine kinase ( CK ) and its isoenyme ( CK - MM ) through observing their dynamic < ...

80. Production of PA in vivo in plants is through the pathways of two signals of phospholipases C and D, and the former induces effect in cooperation with diacylglycerol kinase.

81. Phosphorylation and dephosphorylation of protein was a regulation mechanism generally existed in the organism, Kinase played an important role in signal conduction way of ABA mediated.

82. Objective To investigate the effect of protein kinase B and its phosphorylation on the apoptosis of MIN6 induced by palmitate.

83. Patients with myopathy generally have muscle pain, tenderness or weakness, and an elevation of a muscle enzyme in the blood (creatine kinase).

84. AIM: To examine possible direct effects of the vasodilators hydralazine and KRN2391 on the activities of protein kinase A (PKA) , protein kinase G (PKG), and protein kinase C (PKC).

85. In that situation, the IKKE protein kinase acts as a brake on the metabolism.

86. Objective To evaluate the role of protein kinase C(PKC) in the thermal hyperalgesia evoked by local injection of endothelin-1(ET-1).

87. AIM To explore if nucleoside diphosphate kinase A(NDPK-A)can potentiate the antitumor action of cisplatin.

88. Erlotinib is a small molecule tyrosine kinase inhibitor that efficiently blocks EGFR.

89. Targets such as lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (AST), creatine phosphate kinase (CK MB) in serum were detected as routine.

90. Objective Preparition of monoclone antibody to human thymidine kinase ( hTK ) .

91. Genistein, a natural tyrosine kinase inhibitor, has been reported to inhibit growth and induce apoptosis of various turner cells.

92. The protein, known as AMP - activated protein kinase or AMPK, controls metabolic decisions of cells.

93. In chronic myelogenous leukemia, the target of these drugs is the protein produced by the BCR-ABL gene — tyrosine kinase.

94. Objective To observed the influence of luteolin on protein kinase C activity in human leukemic cells (HL-60).

95. ObjectiveTo observe the effect of 7 flavonoids on recombinant human protein kinase CK2 holoenzyme activity and investigate their structure-activity relationship.

96. AIM: To study the effects and mechanism of mitogen activated protein kinase (MAPK) in cell signal transduction of chronic myelogenous leukemia (CML).

97. Myodynamia, skin rash, serum levels of ALT, AST, LDH and creatinine kinase (CK), as well as drug adverse reactions were kept under observation.

98. CONCLUSION GST can block L-type calcium channel activity in guinea-pig colon smooth muscle cells via tyrosine kinase pathway.

99. PMA is an activator of protein kinase C[http://], which can stimulate phagocyte to produce respiratory burst.

100. FGFR 3, a member of polypeptide growth factor family, is a tyrosine kinase receptor.

101. TPA is a potential tumor promotor and an activator of protein kinase C(PKC).

102. There may be features of autonomic instability, and serum creatine kinase ( CK ) may be elevated.

103. Protein serine theronine phosphatase inhibitor or cyclin dependent kinase ( CDK ) inhibitors could abolish the enhancement.

104. Many leukemic oncogenes form as a consequence of gene fusions or mutation that result in the activation or overexpression of a tyrosine kinase.

105. In the gel autophosphorylation assay of the protein kinase, a 62.5KD CDPK has been identified in the microsome of the grape berries and it was able to be activated by extrinsic ABA.

106. Displays cytostatic and cytotoxic activity. Inhibitor of EGFR kinase. Shows antiangiogenic activity.

107. EGFR tyrosine kinase inhibitor is an investigative hot spot in targeted therapy of non-small cell lung cancer(NSCLC).

108. The inhibitor of VEGF receptor tyrosine kinase was introduced in detail.

109. In this experiment, phylogenetic relationships of 18 species of passerines were studied using Adenylate Kinase Intron 5 (AK5) sequences and DNA techniques.

110. This study was designed to explore the influence of STI571, a tyrosine kinase inhibitor, on the expression of c kit in the bone marrow cells from patients with acute non lymphocytic leukemia (ANLL).

111. The invention provides methods for the treatment of tyrosine kinase inhibitor resistant cancers with anti-EGFR antibodies.

112. Regulation of glycolysis The main control step is that catalyzed by PFK but hexokinase and pyruvate kinase are additional control sites.

113. Furthermore, EGFR kinase inhibition induces HER kinase receptors to engage in alternative dimerization that can ultimately influence therapeutic selection and responsiveness.

114. Objective To investigate the mitogen-activated protein kinase(MAPK)signal transduction pathway induced by fibronectin(FN) in human fetal lung fibroblast cells (HFL1).

115. Objective To investigate the role of ribosomal S6 kinase (RSK) in the pathogenesis of rat hepatic fibrosis.

116. Therefore, the aim of this study is to investigate the effects of genistein, a protein tyrosine kinase inhibitor, on acute and chronic inflammation in diabetic mice (induced by streptozotocin).

117. Objective: To explore the effect of extracellular signal-regulated kinase(ERK) on the apoptosis induced by bufalin in K562 cells.

118. Objective To study the effect of protein kinase (PKA) on catelamine (CA) secretion in rat adrenal chromaffin cells.

119. The recombinant KDR - CD was identified to have kinase activity catalyzing theATP in the enzymatic reaction.

120. A 3D database searching was conducted with 3DFS in 3D database using the pharmacophore of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors.

121. Objective To study the effects of high glucose on activity of mitogen activated protein kinase (MAPK) in cultured human mesangial cells and to explain the mechanism of diabetic nephropathy.

122. This is the first, and, to date, only trial of an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to show a survival advantage for patients with advanced non-small cell lung cancer.

123. Method The activity of tyrosine protein kinase(TPK) was determined by using exogenic substrates in 16 samples of normal skin, 22 psoriatic lesion and 5 skin squamous carcinoma.

124. AIM To study the effects and kinetics of sodium quercetin 7 sulphate (SQMS) on recombinant human protein kinase CK2 holoenzyme.

125. Recently, tit in has been to signal transduction through its kinase domain to sense mechanical load.

126. The abnormal activity of tyrosine protein kinase was the cause with endometrium abnormal growth.

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127. Objective To discuss the relationship between estradiol and the mitogenic activated protein kinase signal transduction pathway and the expression of the MAPK in the MCF-7 breast cancer cell-line.

128. AIM To investigate the effect of acute and chronic lead exposure on CA1 long term potentiation(LTP) and active extracellular signal regulated kinase 2(ERK2) of rat hippocampus.

129. The change of tyrosine phosphatase activity following the kinase reflects the real time regulation of phosphorylation and dephosphorylation.

130. Protein tyrosine kinase(PTK) inhibitor is one of the new targets of oncotherapy.

131. Sphingosine kinase (SPK) is a key enzyme catalyzing the formation of sphingosine 1 phosphate (S1P), which is a lipid messenger with strong angiogenic activity.

132. AIM: To observe the inhibitory effect of luteolin on recombinant human protein kinase CK2 holoenzyme and to confirm the inhibitory type by its enzyme kinetic analysis in vitro.

133. The results showed that exogenous ethylene could increase ethylene production by 420% and 73%, reduce the activity of NAD kinase by 20% and 40% and had no obvious effects on NADP phosphatase activity.

134. The content of water and MDA in myocardium and creatin kinase (CK) in the coronary effluent were measured.

135. Adenylate kinase(AK) is a phosphotransferase enzyme that catalyzes the interconversion of adenine nucleotides, and plays an important role in cellular energy homeostasis.

136. Gefitinib is protein tyrosine kinase inhibitor of a selective EGFR, can block the signal transduction pathway of tyrosine protein kinase, and then promote tumor cell apoptosis.

137. This study was to search specific CK2 inhibitors in tumor cells through observation of the inhibitory effects of baicalein on recombinant human protein kinase CK2 holoenzyme and its kinetic.

138. D5 is homologous with M-CK gene (muscle creatine kinase) and located at Gallus gallus chromos 32 bye-PCR on NCBI.