(1) After treated with bufalin , the expressions of protein p 16, p 21 and pRb were up - regulated.

(2) Objective: To investigate the effect of bufalin on inducing cell apoptosis in human acute lymphoblastic cell line CCRF-CEM.

(3) Conclusion:ERK negatively regulated the apoptosis induced by bufalin in K562 cells.

(4) Conclusion Bufalin is effective to inhibit the growth of mice S180 sarcoma.

(5) Result Bufalin had inhibition growth effect on ECV304 cells with different level, and had concentration and time dependence.

(6) Conclusion The combination of ATRA with bufalin can significantly enhance the differentiation of NB4 cells in vitro culture by ATRA.

(7) Objective:To study the effect of bufalin on the growing the apoptosis of the HL-60/ADR cells.

(8) Bufalin induced apoptosis of HL 60 cells was inhibited by ZnCl 2, an inhibitor of endonuclease, but not by cycloheximide, an inhibitor of protein synthesis.

(9) Conclusion Bufalin can inhibit the proliferation of vascular endothelial cell and has anti-angiogenesis effect.

(10) In contrast, APL cells of two cases showed synergistic differentiation after treatment with ATAR and bufalin.

(11) Objective: To explore the effect of extracellular signal-regulated kinase(ERK) on the apoptosis induced by bufalin in K562 cells.