1) Objective To investigate the effect of hirudin on brain edema and brain injuries after intracerebral hemorrhage.

2) The successful display of hirudin on the surface of M13 phage laid a sound foundation for the further study on directed evolution of antithrombotic proteins with altered properties.

3) CONCLUSION The transport of recombinant hirudin across xenopus pulmonary membrane was a passive diffusion process which was energy-independent and carrier-independent.

4) However, low production of natural hirudin, which was very expensive, limiting its use of in clinical practice.

5) PurposeThe aim is to obtain recombinant hirudin gene using PCR method.

6) Hirudin is an anticoagulant directly acting on thrombin. Its molecular biological and pharmacological properties, mechanism of action, current clinical researches and uses were reviewed.

7) CONCLUSIONS:Hirudin could prevent PVR from being formed or developing and had protective function on retina, whose mechanism related to the decrease of density of PDGF in vitreous body.

8) AIM:To evaluate the effect of recombinant hirudin (r hirudin) in reducing neointimal proliferation after balloon angioplasty in rabbits.

9) Administration of hirudin reduced both brain water content and BBB permeability.

10) Results The drug content of prepared recombinant hirudin coated-pellets was 3.513%(w).

11) ConclusionThe experiments show that hirudin active factors have strong inhibition effect on S180 Tumor and CAM angiogenesis.

12) And the fibrinogen method in vitro and a canine blood coagulation model were used to identify how batroxobin antagonize the bleeding effect of hirudin.

13) Conclusion Thrombin can lead to brain edema after cerebral hemorrhage which can be restrained by Hirudin. And then, hirudin doesn't produce any negative effect on brain tissue.

14) OBJECTIVE Progress in different routes of administration and formulations for Hirudin are reviewed.

15) Conclusion Damage to the thalamic tissue might be caused by thrombin and reversed by hirudin.

16) AIM To investigate the apoptotic effect of thrombin on brain microvascular endothelial cell(BMVEC) of cultured rat, and the protective effect of hirudin,[http:///hirudin.html] an inhibitor of thrombin.

17) Conclusion Thrombin lead to brain edema after cerebral hemorrhage that could be restrained by hirudin, and hirudin didn't produce any negative effect on brain tissue.

18) Objective To investigate the mechanism of brain injury caused by thrombin and the intervention effect of hirudin and nimodipine.