1 Objective To review the advances on lovastatin fermentation by Aspergillus terrus.

2 Objective To study the effect of lovastatin on the cell cycle and proliferation of human highly metastatic ovarian carcinoma HO-8910PM cells.

3 In the process of manufacturing Lovastatin Tablets, two kinds of refuses, fermentation refuse and refining refuse, are produced.

4 Average recovery rate of the lovastatin mother liquor is 65 %, and average content of lovastatin is 72%.

5 Protective effects of lovastatin on vascular endothelial function were reversed by L-NNA.

6 Methods: Simvastatin was synthesized from lovastatin via several steps involving acetylization, methylation , hydrolytic decomposition and cyclization reactions.

7 Objective To construct one of yield lovastatin strain that is a very valid medicine for cholesterol - lowering.

8 These experiments confirmed the existence of Lovastatin again in P. citrinopileatus and provided evidence for its function of lowering serum lipids.

9 Methods: Simvastatin was synthesized from lovastatin via acetylization, methylation, hydrolytic decomposition and cyclization reactions.

10 Conclusion Lovastatin could inhibit the proliferation of HL-60 cell lines in vitro, and the effect of lovastatin on cell cycle and cell apoptosis maybe play key role.

11 Methods A total of 180 patients with hyperlipidemia were randomly assigned into the metronidazole combined with lovastatin group or the metronidazole alone group.

12 Conclusion The UV method can be used in the quality control of lovastatin sustained-release tablets.

13 Ultraviolet spectrometry and HPLC were used to determine the content of Lovastatin capsule. In the meantime, we compared the results by the two means.

14 Objective To investigate the effect of mean - dose Lovastatin in the treatment of essential hyperlipidemia.

15 AIM: To develop a high-performance liquid chromatography-mass spectrometry (HPLC-MS) method for the determination of lovastatin concentration in human plasma.

16 Objective To evaluate the efficacy and safety of domestic lovastatin.

17 Objective To establish the method of detecting release of nicotinic acid in lovastatin - nicotinic acid sustained tablets.

18 Objective: To establish a UV method for the dissolution determination of lovastatin tablet.

19 OBJECTIVE To study the in vitro and in vivo characters of Lovastatin sustained-releasing tablets.

20 After flight, the strain was rejuvenized, segregated and selected. The content of Lovastatin produced in the solid fermentation was examined.