(1) The coordination of the centrosome cycle and cell cycle ensures an accurate distribution of genetic material.

(2) The centrosome probably plays an important role in the reorganization of the cell that occurs during differentiation.

(3) Centrosome duplication is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division.

(4) Therefore, tumor cell gene instability and centrosome abnormalities are closely related to.

(5) The centrosome, the major microtubule organizing center regulates cell division through forming bipolar mitotic spindles and plays an essential role in the maintenance of chromosomal stability.

(6) Overexpression of STK15 induces increased numbers of centrosome, aneuploidy, and transformation of the cells.

(7) Malfunctions in centrosome cohesion and separation, in fact, have been seen in many solid tumors.

(8) Centrosome A structure found in all eukaryotic cells, except fungi, that forms the SPINDLE during cell division.

(9) The study of regulation mechanism about centrosome replication can play an important role in early diagnosis and treatment of tumor.

(10) IntroductionThe centrosome is the major microtubule organizing center ( MTOC ) of mammalian cells.

(11) The roles of centrosome abnormality in the origination and development of cancers, especially in bladder transitional cell carcinoma are reviewed.

(12) Centrosome is a kind of tiny cellular organ, and it plays an important role in the maintenance of cellular polarity and chromosomal segregation during mitosis.

(13) Perturbation of the spatiotemporal dynamics of centrosome splitting can lead to genomic instability during cell division.

(14) With development of the research, the complicated function of centrosome and its im-portance have gradually been realized.

(15) Accordingly, the researchers have proved that these checkpoint kinases also exist alongside the centrosome and perform their function there.

(16) The cell cycle arrest is transient, and GSCs appear to re-enter the cell cycle on correction of centrosome orientation.

(17) The entire cell aster with the exception of the centrosome .

(18) Relatively little is known about the inner workings of centrosomes even after a century of study, and the investigators suggest their discovery could explain centrosome evolution and function.

(19) They form a connection between the starting point in the chromosomes , the kinetochore, and the centrosome.

(20) Aurora kinases play important roles in many events during cell mitosis, such as centrosome maturation and separation, spindle assembly and maintenance, chromosome segregation, cytokinesis and so on.