1. Toxicity includes headache, peeling of skin , hepatosplenomegaly , and bone thichening.

2. There was no hepatosplenomegaly or lymphadenopathy, but severe exfoliative dermatitis was observed.

3. Repeated ultrasound examination reealed mild hepatosplenomegaly and enlarged peripancreatic lymph nodes.

4. There was no hepatosplenomegaly or regional lymphadenopathy, but severe exfoliative dermatitis was observed.

5. Main manifestation of the clinical symptoms were enlargement of lymph nodes, fever, hepatosplenomegaly, skin rash, rapid red cell sedimentation rate and polyclonal hyperglobulinemia.

6. And more activities the great toe, Shugan Jianpi, increase appetite, also have the Hepatosplenomegaly supporting effect.

7. Conclusion Awareness of diagnosis of HPS is crucial when patients have unknown hepatic dysfunction, fever, hepatosplenomegaly and pancytopenia.

8. Objective The previously reported clinical findings in patients with sea blue histiocytosis (SBH) in China included hepatosplenomegaly, anemia and thrombocytopenia.