1. This is caused by neurosyphilis.

2. Neurosyphilis : is an infection of the brain or spinal cord.

3. An extensive laboratory evaluation confirmed the diagnosis of neurosyphilis and diabetes mellitus.

4. Results All patients were diagnosed as interstitial neurosyphilis by pathological examination after operation. Meningeal syphilis was found in 1 case and meningovascular syphilis in 2 cases.

5. Objective To analyse the clinical features of neurosyphilis in order to help early diagnosis.

6. Neurosyphilis; Clinical manifestations; Diagnosis.

7. Methods A retrospective analysis in 3 cases of neurosyphilis diagnosed by clinical and laboratory examinations was focused on their clinical manifestations.

8. Results The clinical features of neurosyphilis: (1)Acute or subacute onset was common, while chronic onset was minority.

9. Objective To investigate the prevalence of asymptomatic neurosyphilis in patients with persisting positive RPR and its clinical significance.

10. Conclusion Neurosyphilis has a high misdiagnosis rate, and its diagnosis depends on clinical manifestations, laboratory and imaging examinations.

11. Conclusion Asymptomatic neurosyphilis in some patients may be one of causes of persisting positive RPR.

12. Specific change was not found on the CT and MRI of cranium. Conclusion Initial symptoms of neurosyphilis have various patterns of manifestation .

13. There is no golden standard available now in diagnosing neurosyphilis.

14. Seizures and focal neurologic deficits may be the complications of neurosyphilis, but status epilepticus as a presenting picture of neurosyphilis is rare.

15. Objective To explore the clinical characteristics of craniocerebral surgery in the patients with neurosyphilis.

16. Objective To analyze the significance of several methods in diagnosis of neurosyphilis for understanding the incidence of asymptomatic neurosyphilis.

17. Objective To analyze the typing and clinical characteristics of neurosyphilis of brain and provide evidences to improve early diagnostic.

18. Objective To evaluate the value and limitation of MRI in the diagnosis of meningovascular neurosyphilis.